Figure 4

Transmitter envelope viruses have higher replication compared to recipient envelope viruses in monocyte derived dendritic cells (MDDC) – autologous CD4+ T cell cultures. Recipient relative to transmitter envelope virus replication AUC among mature MDDCs – autologous CD4+ T cells (A) and immature MDDCs – autologous CD4+ T cells (B) from blood donation volunteer 1 (circle), 2 (square), 3 (triangle), and 4 (star) respectively. The x-axis shows the couple’s ID. The dotted line at a ratio of 1 separates instances when the recipient envelope viruses replicated to a greater extent than the transmitter envelope viruses (> 1) or vice-versa (< 1). The bottom graphs show correlation between interval from estimated infection to sampling and recipient to transmitter replication AUC ratio in mature MDDC (C) and immature MDDC (D). Graphs also shows the correlation coefficient with the Spearman rank correlation p - values.