Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins

Retrovirology

Table 1 Cytidine deaminase activity and inhibitory potency of AID/APOBEC proteins against hL1, ZfL2-2 and ZfL2-1 retroelements

AID/APOBEC protein family
Tested protein	CDA in *E. coli*	Inhibition of retrotransposition
Tested protein	CDA in *E. coli*	hL1	ZfL2-2	ZfL2-1
A3A	+ ¹	+++ ^*,2	+++ ^*	+++ ^*
A3B	+ ^1,3	+++ ^*,4	+++ ^*	ND
A3C	+ ⁵	++ ^*,6	++ ^*	ND
A3F	+ ⁷	++ ^*,4	++ ^*	ND
A3D	ND, edits viral cDNA ⁸	– ^*,4	– ^*	ND
A3G	+ ⁵	– ^*,4	– ^*	ND
A3H	+ ¹⁰	– ^*,11	– ^*	ND
hA1	+ ⁵	+ ^* / ++ ¹²	– ^*	+ ^*
hA2	– ⁵	– ^*,2	– ^*	ND
hAID	+ ⁵	– ^*,6	– ^*	ND
lizA1aF3	+ ^*,13	+ ^*	– ^*	+ ^*
lizA1aF8	+ ^*,13	+ ^*	– ^*	+ ^*
zfAID	+ ^*,14	– ^* / +¹⁴	– ^*	– ^*
zfA2a	– ^*	– ^*	– ^*	– ^*
zfA2b	+ ^*	– ^*	– ^*	– ^*

The basic structural differences of the tested retrotransposons are schematically represented. *, results of this study; +++, 70% inhibition; ++, 50% inhibition; +, 30% inhibition; ND, not determined; 1, [51]; 2, [49]; 3, [71]; 4, [65]; 5, [62]; 6, [66]; 7, [77]; 8, [78]; 9, [50]; 10, [31]; 11, [53]; 12, [55]; 13, [24]; 14, [56].

ISSN: 1742-4690