Figure 3

Relationship between the IFN resistance of acute time-point virus isolates and the setpoint persisting viral load established in the subjects from which they were derived. (A) IC₅₀ values; and (B) Vres values of plasma virus isolates generated from different subjects during acute HIV infection are plotted against the setpoint persisting viral load subsequently established in the individual concerned in the absence of ART. Solid circles denote IC₅₀ and Vres data for IFN-α and open triangles denote IC₅₀ and Vres data for IFN-β. The data shown are the mean of results from a minimum of 2 independent IFNα or IFNβ assays performed with each virus using different donor PBMC mixes.