Figure 2

Structure of Mut101 bound to IN-CCD. (A) Zoomed view highlighting the hydrogen bonds between Mut101 (in green) and the IN-CCD dimer (in gold and blue). (B) Superimposition of the IN-CCD structures solved with (gold) and without (blue) Mut101. Two regions show significant differences and are highlighted by a white rectangle. (C-D) Enlargement of the two regions C and D showing the conformational changes upon ligand binding. (E-F) Solvent accessible surface coloring of IN monomers in red and gold, in absence (E) and in presence (F) of MUT101. Nitrogen atoms are in blue, oxygen in red and sulfur in yellow. Mut101 is represented in cyan. The position of K173 and E96 are shown on each monomer. The figure was made using PyMOL [73].