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Table 4 Positive selective pressure on the Env glycoproteins in both children over the course of infection

From: Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

Env glycoprotein

Codons under selective pressure (location)1

Child 1

Child 2

Year of birth

Year 2

Year 5

Year of birth

Year 5

Year 9

gp125

none

5, 7 (in SP)

178 (V2), 255, 259 (C2), 320 (V3), 459 (V5), 467, 471 (C5)

none

none

395 (C3)

gp36

none

none

552 (HR1), 672, 673 (MPER)

none

none

562 (HR1)

  1. 1Codons identified as being significantly (P <0.05) under selective pressure are indicated; SP, signal peptide; V2, variable region 2; C2, conserved region 2; C3, conserved region 3; V3, variable region 3; V5, variable region 5; C5, conserved region 5; HR1, helical region 1; MPER, membrane proximal external region.