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Table 1 Virological and immunological characterization of the patients

From: Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

Patient Sampling year Age (Years) Viral load (RNA copies/ml plasma) Viral tropisma Number of CD4+T cells/μl (%) Drug regimen Disease stageb
Child 1 1998 0.11c <200 R5 5342 (47) - N
1999 1 <200 nd 2992 (50) - N
2000 2 1355 R5 2919 (43) - A1
2001 3 nd nd 3253 (51) - A1
2003 5 20968 X4 595 (27) d4T + 3TC + LPV/RTV B2
2006 8 <200 nd 1895 (55) d4T + 3TC + LPV/RTV A1
2010 12 <40 nd 1878 (54) 3TC + ABC + LPV/RTV A1
Child 2 1992 0.07d <200 R5e 1670 (52) AZT C1
1997 5 <200 X4 1050 (25) AZT C1
1999 7 13883 nd 127 (15) AZT C1
2001 9 1250 X4 44 (5) AZT + 3TC C3 (death)
  1. aAs determined phenotypically in TZMbl cells [22] or genotypically based on V3 loop sequence patterns [36]; bAccording to the CDC revised classification system for HIV infection in children; cFirst blood collection was at day 39 after birth; dFirst blood collection was at day 27 after birth; eIsolate obtained at birth was syncytium inducing as determined in PBMCs and several cell lines [32]; d4T–stavudine, 3TC–lamivudine, LPV–lopinavir, RTV–ritonavir, ABC–abacavir, AZT–zidovudine; nd–not determined.