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Figure 1 | Retrovirology

Figure 1

From: A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

Figure 1

Akv constructs. (a) LoxP sites in Akv-2XY were inserted between the 5'LTR and gag and between the env and the 3'LTR. (b) The Akv-Y provirus contained IRES-EYFP in the U3 region of the LTR. (c) The Akv-2XY provirus contained IRES-EYFP and two LoxP sites flanking the Akv structural genes. (d) Cre-mediated recombination of the LoxP sites in Akv-2XY results in deletion of the viral genes. Each of the proviruses contained two BsrG1 sites, B. The sizes (kb) of DNA segments generated by BsrG1 are above each construct.

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Retrovirology

ISSN: 1742-4690

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