Table 1 FIV Protease Escape Mutants (HIV equivalent residue)
From: Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3
PR mutations | Ki vs TL-3 (nM) | |
|---|---|---|
Wildtype PR | ---- | 9.9 |
Cat 231 | D105G (HIV88N) | 47.3 |
D94G (*) | N.D. | |
H72R (HIV63L) | 10.9 | |
N55D (HIV46M) | 9.1 | |
G52R (HIV43K) | N.D. | |
1M107R (HIV90L) | inactive | |
1N51Y (HIV42W) | N.D. | |
Cat 228 | C69R (HIV60D) | N.D. |
Cat 222 | D105G (HIV88N) | 47.3 |