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  1. Content type: Research

    Semen is a critical vector for human immunodeficiency virus (HIV) sexual transmission and harbors seminal amyloid fibrils that can markedly enhance HIV infection. Semen-derived enhancer of viral infection (SEV...

    Authors: Ruxia Ren, Shuwen Yin, Baolong Lai, Lingzhen Ma, Jiayong Wen, Xuanxuan Zhang, Fangyuan Lai, Shuwen Liu and Lin Li

    Citation: Retrovirology 2018 15:49

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  2. Content type: Research

    Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indic...

    Authors: Joris Paris, Joëlle Tobaly-Tapiero, Marie-Lou Giron, Julien Burlaud-Gaillard, Florence Buseyne, Philippe Roingeard, Pascale Lesage, Alessia Zamborlini and Ali Saïb

    Citation: Retrovirology 2018 15:48

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  3. Content type: Research

    The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary obstacle to curing these infections. Quantitative viral...

    Authors: Art F. Y. Poon, Jessica L. Prodger, Briana A. Lynch, Jun Lai, Steven J. Reynolds, Jingo Kasule, Adam A. Capoferri, Susanna L. Lamers, Christopher W. Rodriguez, Daniel Bruno, Stephen F. Porcella, Craig Martens, Thomas C. Quinn and Andrew D. Redd

    Citation: Retrovirology 2018 15:47

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  4. Content type: Research

    Co-infection with avian leukosis virus subgroup J and reticuloendotheliosis virus induces synergistic pathogenic effects and increases mortality. However, the role of exosomal miRNAs in the molecular mechanism...

    Authors: Defang Zhou, Jingwen Xue, Shuhai He, Xusheng Du, Jing Zhou, Chengui Li, Libo Huang, Venugopal Nair, Yongxiu Yao and Ziqiang Cheng

    Citation: Retrovirology 2018 15:45

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  5. Content type: Research

    Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protec...

    Authors: Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke and Masafumi Takiguchi

    Citation: Retrovirology 2018 15:46

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  6. Content type: Research

    Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascad...

    Authors: Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Ming Li, Mark R. Chance and John C. Tilton

    Citation: Retrovirology 2018 15:44

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  7. Content type: Research

    The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency...

    Authors: Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi and Andrew J. Mouland

    Citation: Retrovirology 2018 15:42

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  8. Content type: Research

    HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functi...

    Authors: Andrey Ivanov, Xionghao Lin, Tatiana Ammosova, Andrey V. Ilatovskiy, Namita Kumari, Hatajai Lassiter, Nowah Afangbedji, Xiaomei Niu, Michael G. Petukhov and Sergei Nekhai

    Citation: Retrovirology 2018 15:39

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  9. Content type: Research

    Hosts are able to restrict viral replication to contain virus spread before adaptive immunity is fully initiated. Many viruses have acquired genes directly counteracting intrinsic restriction mechanisms. This ...

    Authors: Carmen Ledesma-Feliciano, Sarah Hagen, Ryan Troyer, Xin Zheng, Esther Musselman, Dragana Slavkovic Lukic, Ann-Mareen Franke, Daniel Maeda, Jörg Zielonka, Carsten Münk, Guochao Wei, Sue VandeWoude and Martin Löchelt

    Citation: Retrovirology 2018 15:38

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  10. Content type: Research

    Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells. A limited number of studies have demonstrated add...

    Authors: Georges Khoury, Talia M. Mota, Shuang Li, Carolin Tumpach, Michelle Y. Lee, Jonathan Jacobson, Leigh Harty, Jenny L. Anderson, Sharon R. Lewin and Damian F. J. Purcell

    Citation: Retrovirology 2018 15:36

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  11. Content type: Short report

    Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity an...

    Authors: Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe and Ali Bazarbachi

    Citation: Retrovirology 2018 15:33

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  12. Content type: Research

    The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) gene family appears only in mammalian genomes. Some A3 proteins can be incorporated into progeny virions and inhibit lentivir...

    Authors: Yoriyuki Konno, Shumpei Nagaoka, Izumi Kimura, Keisuke Yamamoto, Yumiko Kagawa, Ryuichi Kumata, Hirofumi Aso, Mahoko Takahashi Ueda, So Nakagawa, Tomoko Kobayashi, Yoshio Koyanagi and Kei Sato

    Citation: Retrovirology 2018 15:31

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  13. Content type: Review

    Among the different markers of HIV persistence in infected cells, total HIV DNA is to date the most widely used. It allows an overall quantification of all viral forms of HIV DNA in infected cells, each playin...

    Authors: Christine Rouzioux and Véronique Avettand-Fenoël

    Citation: Retrovirology 2018 15:30

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  14. Content type: Research

    The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four-helix collar underneath trime...

    Authors: Dehua Liu, Hongyun Wang, Mizuki Yamamoto, Jiping Song, Rui Zhang, Qingling Du, Yasushi Kawaguchi, Jun-ichiro Inoue and Zene Matsuda

    Citation: Retrovirology 2018 15:27

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  15. Content type: Research

    The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that restrict many viruses, including HIV-1. SAMHD1 is another restriction factor blocking replication of HIV-1 and other v...

    Authors: Ferdinand Roesch, Molly OhAinle and Michael Emerman

    Citation: Retrovirology 2018 15:26

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  16. Content type: Research

    NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the interaction between the HIV-1 (ψ) stem-loop 3 (SL3) ...

    Authors: Carin K. Ingemarsdotter, Jingwei Zeng, Ziqi Long, Andrew M.L. Lever and Julia C. Kenyon

    Citation: Retrovirology 2018 15:25

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