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  1. Research

    Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

    The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from C...

    Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, Zhepeng Liu, Shuai Liu, Panpan Hou, Li Zhou, Wei Hou, Wenzhe Ho, Chunmei Li, Li Wu and Deyin Guo

    Retrovirology 2017 14:51

    Published on: 15 November 2017

  2. Research

    The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

    HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, th...

    Céline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Erwann Le Rouzic, Laia Miralles, Julie Brias, Francis Chevreuil, Daniele Spehner, Sophie Chasset, Benoit Ledoussal, Luzia Mayr, François Moreau, Felipe García, José Gatell…

    Retrovirology 2017 14:50

    Published on: 9 November 2017

  3. Correction

    Correction to: Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

    The authors wish to apologize for an error within the scale bar of the microarray heatmap in Additional File 5 of the supplementary information. Two values were incorrectly displayed on the scale bar (11 inste...

    Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach

    Retrovirology 2017 14:48

    Published on: 18 October 2017

    The original article was published in Retrovirology 2017 14:34

  4. Research

    Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

    In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrop...

    Eugene L. Asahchop, Oussama Meziane, Manmeet K. Mamik, Wing F. Chan, William G. Branton, Lothar Resch, M. John Gill, Elie Haddad, Jean V. Guimond, Mark A. Wainberg, Glen B. Baker, Eric A. Cohen and Christopher Power

    Retrovirology 2017 14:47

    Published on: 16 October 2017

  5. Short report

    A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

    Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strong...

    Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson and Feng Gao

    Retrovirology 2017 14:46

    Published on: 10 October 2017

  6. Research

    Cellular fatty acid synthase is required for late stages of HIV-1 replication

    Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purin...

    Manjusha M. Kulkarni, Annette N. Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Jesus Arcos, David Loiselle, Jordi B. Torrelles, Nicholas T. Funderburg, Timothy A. Haystead and Jesse J. Kwiek

    Retrovirology 2017 14:45

    Published on: 29 September 2017

  7. Research

    Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

    The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutra...

    Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni and Shuzo Matsushita

    Retrovirology 2017 14:44

    Published on: 22 September 2017

  8. Research

    HIV-1 tolerates changes in A-count in a small segment of the pol gene

    The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not...

    Bep Klaver, Yme van der Velden, Formijn van Hemert, Antoinette C. van der Kuyl and Ben Berkhout

    Retrovirology 2017 14:43

    Published on: 5 September 2017

  9. Research

    Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection

    Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model,...

    Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng, Lieping Chen, Ulf Dittmer and Gennadiy Zelinskyy

    Retrovirology 2017 14:42

    Published on: 23 August 2017

  10. Research

    Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers

    Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and while the majority are transcriptionally silent, the most recently integrated HERV, HERV-K (HML-2), remains active. Durin...

    Miguel de Mulder, Devi SenGupta, Steven G. Deeks, Jeffrey N. Martin, Christopher D. Pilcher, Frederick M. Hecht, Jonah B. Sacha, Douglas F. Nixon and Henri-Alexandre Michaud

    Retrovirology 2017 14:41

    Published on: 22 August 2017

  11. Research

    Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

    Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodel...

    Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne and Vincent Parissi

    Retrovirology 2017 14:39

    Published on: 28 July 2017

  12. Obituary

    Tribute to Mark Wainberg

    Eric J. Arts, Anne Gatignol, Andrew J. Mouland, Chen Liang, Matthias Götte and Hugo Soudeyns

    Retrovirology 2017 14:38

    Published on: 28 June 2017

  13. Review

    HIV drug resistance against strand transfer integrase inhibitors

    Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA ge...

    Kaitlin Anstett, Bluma Brenner, Thibault Mesplede and Mark A. Wainberg

    Retrovirology 2017 14:36

    Published on: 5 June 2017

  14. Short report

    Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee

    Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpan...

    Hannah J. Barbian, Raven Jackson-Jewett, Corrine S. Brown, Frederic Bibollet-Ruche, Gerald H. Learn, Timothy Decker, Edward F. Kreider, Yingying Li, Thomas N. Denny, Paul M. Sharp, George M. Shaw, Jeffrey Lifson, Edward P. Acosta, Michael S. Saag, Katharine J. Bar and Beatrice H. Hahn

    Retrovirology 2017 14:35

    Published on: 2 June 2017

  15. Research

    Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

    Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or les...

    Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach

    Retrovirology 2017 14:34

    Published on: 31 May 2017

    The Correction to this article has been published in Retrovirology 2017 14:48

  16. Research

    Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup

    Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO...

    Nadine Bachmann, Teja Turk, Claus Kadelka, Alex Marzel, Mohaned Shilaih, Jürg Böni, Vincent Aubert, Thomas Klimkait, Gabriel E. Leventhal, Huldrych F. Günthard and Roger Kouyos

    Retrovirology 2017 14:33

    Published on: 23 May 2017

  17. Review

    A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

    Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBE...

    Yusuke Nakano, Hirofumi Aso, Andrew Soper, Eri Yamada, Miyu Moriwaki, Guillermo Juarez-Fernandez, Yoshio Koyanagi and Kei Sato

    Retrovirology 2017 14:31

    Published on: 8 May 2017

  18. Editorial

    Professor Mark Wainberg

    Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia, Paul Gorry, Andrew Lever, Johnson Mak, Monique Nijhuis, Klaus Strebel, Francois Venter and Robin Weiss

    Retrovirology 2017 14:30

    Published on: 5 May 2017

  19. Research

    Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers

    Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at ...

    Suwellen S. D. de Azevedo, Diogo Gama Caetano, Fernanda H. Côrtes, Sylvia L. M. Teixeira, Karina dos Santos Silva, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado and Gonzalo Bello

    Retrovirology 2017 14:29

    Published on: 2 May 2017

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