Volume 6 Supplement 3

AIDS Vaccine 2009

Meeting abstracts

Edited by Anna Laura Ross

AIDS Vaccine 2009. Go to conference site.

Paris, France19-22 October 2009

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Page 2 of 10

Content type: Poster presentation

P03-09. Preserved adaptive immune responses and limited immune activation in CD4-low SIV-positive sooty mangabeys

Authors: KD Mir, JM Milush, JM Brenchley, JD Reeves, SN Gordon, JG Else, E O'Neill, G Silvestri and DL Sodora

Citation: Retrovirology 2009 6(Suppl 3):P26

Published on: 22 October 2009
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OA04-02. Strong HIV-specific CD4 and CD8 T-lymphocyte proliferation in HIV-1 DNA prime/modified vaccinia virus Ankara (MVA) heterologous boost vaccinees

Authors: C Nilsson, S Aboud, K Karlén, M Marovich, B Wahren, E Sandström, H Gaines, G Biberfeld and K Godoy-Ramirez

Citation: Retrovirology 2009 6(Suppl 3):O26

Published on: 22 October 2009
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P03-10. Induction of neutralizing antibodies in Rhesus macaques following mucosal challenge with R5 tropic SHIV162P3 isolate

Authors: H Chung, L Galmin, J Suschak, D Weiss, L Finke, D Montefiori and R PAL

Citation: Retrovirology 2009 6(Suppl 3):P27

Published on: 22 October 2009
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OA04-03. Characterization of cell-mediated immune responses generated by recombinant modified vaccinia Ankara (rMVA)-HIV-1 in a phase I vaccine trial

Authors: JR Currier, M De Souza, S Ratto-Kim, R Paris, V Nguay, J Cox, P Earl, B Moss, S Sriplienchan, P Thongcharoen, J Kim, M Robb, N Michael and M Marovich

Citation: Retrovirology 2009 6(Suppl 3):O27

Published on: 22 October 2009
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OA04-04. Perceived parental willingness for their adolescents to participate in future HIV prevention trials: a survey conducted amongst adolescents in Soweto

Authors: K Otwombe, J Dietrich, K Sikkema, G de Bruyn, M van der Watt and G Gray

Citation: Retrovirology 2009 6(Suppl 3):O28

Published on: 22 October 2009
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P03-11. DNA vaccination with IL-12 lowers viral replication following SIVmac251 challenge

Authors: LA Hirao, L Wu, AS Khan, A Dai, J Karl, S Lank, R Wiseman, D O'Connor, D Watkins, N Miller, MR Betts, NY Sardesai, JD Boyer and DB Weiner

Citation: Retrovirology 2009 6(Suppl 3):P28

Published on: 22 October 2009
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P04-01. Simultaneous enumeration of HIV-1 gp41 Env-specific IgG and IgM antibody-secreting cells with a multiplex B-cell fluorospot assay

Authors: M Bonsignori, K Hwang, N Vandergrift, MA Moody and BF Haynes

Citation: Retrovirology 2009 6(Suppl 3):P29

Published on: 22 October 2009
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OA04-05. Safety and viral load changes in HIV-1 infected subjects treated with autologous dendritic immune therapy following ART discontinuation (CTN#239)

Authors: J Routy, M Boulassel, L Mona, V Sylvie, T Cécile, A Jonathan, G John, B Jean-Guy, S Fiona, J Renu, H Don, T Irina, N Charles and RP Sékaly

Citation: Retrovirology 2009 6(Suppl 3):O29

Published on: 22 October 2009
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OA04-06 LB. Post-infection cellular immune responses in recipients following ALVAC-HIV® + AIDSVAX® B/E prime-boost vaccination in the Thai Phase III Trial

Authors: JH Kim, C Kamasuta, R Trichavaroj, J Kaewkungwal, S Chantakulkij, S Ratto-Kim, C Eamsila, S Sukwit, S Nitayaphan, P Pitsuttihum, NL Michael, J Chiu, S Rerks-Ngarm, MS de Souza and RM Paris

Citation: Retrovirology 2009 6(Suppl 3):O30

Published on: 22 October 2009
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P04-02. Increased breadth and potency of the neutralizing antibody response among dually-HIV-1-infected individuals

Authors: RL Powell, T Kinge and P Nyambi

Citation: Retrovirology 2009 6(Suppl 3):P30

Published on: 22 October 2009
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P04-03. Cross-clade neutralization analysis of plasmas from clade B, C and CRF01_AE HIV-infected donors

Authors: J Binley, T Wrin, R Pantophlet, P Phung, ET Crooks, A Lapedes, N Taylor, L Cavacini, G Steigler, R Kunert, H Katinger, C Petropoulos, D Richman, L Morris, R Sutthent and DR Burton

Citation: Retrovirology 2009 6(Suppl 3):P31

Published on: 22 October 2009
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OA05-01. In vivo electroporation enhances the immunogenicity of ADVAX, a DNA-based HIV-1 vaccine candidate, in healthy volunteers

Authors: S Vasan, A Hurley, SJ Schlesinger, D Hannaman, DF Gardiner, DP Dugin, MM Boente-Carrera, RM Vittorino, M Caskey, J Andersen, Y Huang, J Cox, T Tarragona, DK Gill, H Cheeseman, L Clark…

Citation: Retrovirology 2009 6(Suppl 3):O31

Published on: 22 October 2009
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P04-04. The specific phospholipid binding and neutralizing activities of the anti-HIV antibody 4E10 are separable

Authors: H Xu, E Scherer, L Song, M Kim, MA Holmes, G Sellhorn, Z Kraft, EL Reinherz, DR Burton, L Stamatatos and RK Strong

Citation: Retrovirology 2009 6(Suppl 3):P32

Published on: 22 October 2009
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OA05-02. Analysis of DNA compared to Ad5 vaccination, as single and mixed modalities, demonstrates robust induction of cellular immune responses in macaques

Authors: LA Hirao, L Wu, A Satishchandran, AS Khan, A Finnefrock, D Casimiro, J Shiver, MR Betts, NY Sardesai and DB Weiner

Citation: Retrovirology 2009 6(Suppl 3):O32

Published on: 22 October 2009
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OA05-03. Efficacy study of a T-cell-based DNA vaccine delivered by intradermal electrotransfer in macaques

Authors: N Dereuddre-Bosquet, M Baron, I Méderlé-Mangeot, K Kaldma, R Sikut, A Männik, I Stanescu, M Ustav, R Le Grand and F Martinon

Citation: Retrovirology 2009 6(Suppl 3):O33

Published on: 22 October 2009
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P04-05. Requirements for antibody domain exchange explored through mutation of the germline 2G12 antibody

Authors: M Huber, KM Le, KJ Doores and DR Burton

Citation: Retrovirology 2009 6(Suppl 3):P33

Published on: 22 October 2009
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P04-06. Evolution of an anti-MPER gp41 antibody response that mediates broad HIV-1 cross-neutralization

Authors: E Gray, P Moore, N Ranchobe, M Abrahams, M Madiga, K Mlisana, S Abdool-Karim, C Williamson and L Morris

Citation: Retrovirology 2009 6(Suppl 3):P34

Published on: 22 October 2009
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OAO5-04. Gp96-Ig-SIV vaccines induce predominant immune responses at mucosal sites

Authors: N Strbo, M Vaccari, S Pahwa, MA Kolber, E Fisher, L Gonzalez, BK Felber, GN Pavlakis, G Franchini and ER Podack

Citation: Retrovirology 2009 6(Suppl 3):O34

Published on: 22 October 2009
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OA05-05. Impact of in vivo CD4 binding during HIV-1 Env trimer immunizations of rhesus macaques

Authors: I Douagi, MM Forsell, C Sundling, S O'dell, R Seder, JR Mascola, K Loré, RT Wyatt and GB Karlsson Hedestam

Citation: Retrovirology 2009 6(Suppl 3):O35

Published on: 22 October 2009
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P04-07. Guiding the immune system through complex maturation pathways: a novel multi-immunogen approach for elicitation of broadly neutralizing antibodies

Authors: X Xiao, Y Feng, W Chen, N Longo and DS Dimitrov

Citation: Retrovirology 2009 6(Suppl 3):P35

Published on: 22 October 2009
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OA05-06 LB. First-in-human Phase 1 safety and immunigenicity of an adenovirus serotype 26 HIV-1 vaccine vector

Authors: LR Baden, R Dolin, KL O'Brien, P Abbink, A La Porte, MS Seaman, E Choi, R Tucker, M Weitjens, MG Pau, J Goudsmit and DH Barouch

Citation: Retrovirology 2009 6(Suppl 3):O36

Published on: 22 October 2009
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P04-08. Monoclonal antibodies from patient with acute HIV-1 infection

Authors: W Chen, X Xiao, E Streaker, Y Wang, M Markowitz and B Haynes

Citation: Retrovirology 2009 6(Suppl 3):P36

Published on: 22 October 2009
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0A06-01. Multiplicity of infection by HIV-1 in injection drug users, men who have sex with men and heterosexuals

Authors: KJ Bar, H Li, B Keele, T Grayson, R Sun, A Chamberland, C Tremblay, M Markowitz, J Schumacher, B Hahn and G Shaw

Citation: Retrovirology 2009 6(Suppl 3):O37

Published on: 22 October 2009
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P04-09. Induction of cross-clade neutralizing antibodies with a prime/boost vaccine strategy focused on a neutralizing epitope

Authors: S Zolla-Pazner, X Kong, T Cardozo, C Hioe, S Cohen, X Jiang, MK Gorny, M Totrov, A Pinter, C Krachmarov, MS Seaman, S Wang and S Lu

Citation: Retrovirology 2009 6(Suppl 3):P37

Published on: 22 October 2009
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P04-10. Neutralization of Tier 1 and Tier 2 pseudoviruses by human anti-V3 monoclonal antibodies

Authors: MK Gorny, C Williams, T O'Neal, AK Choudhary, K Luthra, B Wood, MS Seaman, P Nyambi and S Zolla-Pazner

Citation: Retrovirology 2009 6(Suppl 3):P38

Published on: 22 October 2009
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OA06-02. Monospecific expansion of SIVmac251 during acute infection masks multiple transmitted virus variants revealed during the chronic phase

Authors: BK Felber, E Kim, R Pal, RC Desrosiers, SM Wolinsky and GN Pavlakis

Citation: Retrovirology 2009 6(Suppl 3):O38

Published on: 22 October 2009
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P04-11. Prevalence of neutralizing antibody responses in chronic clades A and D human immunodeficiency virus type 1 (HIV-1) infections

Authors: HF Njai, K Tomusange, B Sokolik-Wolak, D Montefiori, S Balla, G Vanham, J Levin, D Maher, A Kamali, H Grosskurth, P Pala and P Kaleebu

Citation: Retrovirology 2009 6(Suppl 3):P39

Published on: 22 October 2009
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OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohort

Authors: M Schaefer, J Mulenga, J Tang, P Goepfert, P Farmer, R Kaslow, S Allen and E Hunter

Citation: Retrovirology 2009 6(Suppl 3):O39

Published on: 22 October 2009
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OA06-04. The role of early T-cell responses in subjects with acute HIV-1 infection

Authors: MK Liu, G Ferrari, J Salazar, B Keele, RL Tanner, P Hraber, E Giorgi, VV Ganusov, GH Learn, MG Salazar, SR Moore, K Digleria, Z Yu, T Rostron, C DeBoer, A Williams…

Citation: Retrovirology 2009 6(Suppl 3):O40

Published on: 22 October 2009
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P04-12. Characterization of leukopak PBMC phenotypes and biotypes for optimal performance in HIV-1 neutralization assays

Authors: BK Brown, K Lombardi, M Bryson, J Currier, D Thelian, L Wieczorek, G Kijak, JC Kappes, C Ochsenbauer-Jambor, NL Michael, D Montefiori and VR Polonis

Citation: Retrovirology 2009 6(Suppl 3):P40

Published on: 22 October 2009
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OA06-05. Adaptation of HIV-1 to the human immune system at the population level is driven by protective HLA-B alleles

Authors: IM Schellens, M Navis, HW van Deutekom, B Boeser-Nunnink, B Berkhout, N Kootstra, F Miedema, C Kesmir, H Schuitemaker, D van Baarle and JA Borghans

Citation: Retrovirology 2009 6(Suppl 3):O41

Published on: 22 October 2009
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P04-13. Complex pattern of neutralization of cell-to-cell HIV transmission to activated CD4+T cells

Authors: M Massanella, I Puigdomènech, J Carrillo, B Clotet and J Blanco

Citation: Retrovirology 2009 6(Suppl 3):P41

Published on: 22 October 2009
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OA06-06 LB. Evidence of vaccine-induced changes in breakthrough HIV-1 strains from the Step trial

Authors: M Rolland, S Tovanabutra, PB Gilbert, E Sanders-Buell, L Heath, AC deCamp, CC Magaret, M Bose, A Bradfield, A O'Sullivan, J Crossler, W Deng, H Zhao, K Wong, DN Raugi, J Hural…

Citation: Retrovirology 2009 6(Suppl 3):O42

Published on: 22 October 2009
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P04-14. Sequential HIV-1 isolates from infected individuals reveals emergence of neutralization sensitive HIV-1 strains in the course of infection

Authors: PN Nyambi, S Burda, C Williams, L Heyndrickx, G Vanham and MK Gorny

Citation: Retrovirology 2009 6(Suppl 3):P42

Published on: 22 October 2009
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S03-04 OA. Transitional and central memory CD4 T cells are highly infected in long term non progressors and elite controllers

Authors: B Descours, V Avettand-Fenoël, C Blanc, A Samri, A Mélard, T Prazuck, L Hocqueloux, G Carcelain, C Rouzioux and B Autran

Citation: Retrovirology 2009 6(Suppl 3):O43

Published on: 22 October 2009
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P04-15. Prevalence of broadly neutralizing antibody responses during acute/early HIV infection

Authors: I Mikell, D Sather, S Kalams, M Altfeld and L Stamatatos

Citation: Retrovirology 2009 6(Suppl 3):P43

Published on: 22 October 2009
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S03-05 OA. A less differentiated memory phenotype of Gag-specific CD4+ T-cells during primary HIV infection associates with viral control at 12 months

Authors: PW Maenetje, J Casazza, C Riou, D Ambrozak, G Gray, G de Bruyn, R Koup and C Gray

Citation: Retrovirology 2009 6(Suppl 3):O44

Published on: 22 October 2009
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P04-16. Orally exposed uninfected individuals have systemic anti-HIV response correlating with partner's viral load

Authors: K Hasselrot, G Bratt, T Hirbod, P Säberg, E Sandström and K Broliden

Citation: Retrovirology 2009 6(Suppl 3):P44

Published on: 22 October 2009
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S03-06 OA. Rapid perforin upregulation by CD8 T cells in elite controllers as a correlate of immune-mediated control of HIV replication

Authors: AR Hersperger, F Pereyra, K Demers, P Sheth, LY Shin, B Rodriguez, SF Sieg, L Teixeira-Johnson, PA Goepfert, MM Lederman, R Kaul, G Makedonas, BD Walker and MR Betts

Citation: Retrovirology 2009 6(Suppl 3):O45

Published on: 22 October 2009
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P04-17. The N-glycosylation sites N295, N332 and N392 of gp120 are necessary but not sufficient for HIV-1 to be neutralized by 2G12

Authors: A Chaillon, M Braibant, B Autran and F Barin

Citation: Retrovirology 2009 6(Suppl 3):P45

Published on: 22 October 2009
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P04-18. Comparison of HIV neutralization assays for use in vaccine research and clinical trials, phase II: results from the NeutNet working group

Authors: G Scarlatti, J Alcami, V Bongertz, E Fenyö, A Heath, L Heyndrickx, H Holmes, M Jansson, L Lopalco, M Malnati, D Montefiori, C Moog, L Morris, S Osmanov, V Polonis, M Ramaswamy…

Citation: Retrovirology 2009 6(Suppl 3):P46

Published on: 22 October 2009
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S04-04 OA. HIV-specific responses induced by anti-CD40 targeting antibodies

Authors: N Loof, M Montes, A Flamar, G Zurawski, A Cobb, J Plants, B King, S Zurawski, L Sloan, Y Levy and J Banchereau

Citation: Retrovirology 2009 6(Suppl 3):O46

Published on: 22 October 2009
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P04-19. Analysis of the binding of multiple clades of HIV-1 by a modified virus capture assay

Authors: K Peachman, L Wieczorek, VR Polonis, CR Alving and M Rao

Citation: Retrovirology 2009 6(Suppl 3):P47

Published on: 22 October 2009
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SO4-05 OA. The intracellular production of HIV antigenic peptides is guided by predictable motifs and can be altered: implications for immunogen design

Authors: E Lazaro, S Zhang, M Zhang, S Martinez, D Heckerman, BD Walker and S Le Gall

Citation: Retrovirology 2009 6(Suppl 3):O47

Published on: 22 October 2009
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P04-20. Humoral immune response in acute HIV-1 infection

Authors: L Mainetti, J Mullins and G Scarlatti

Citation: Retrovirology 2009 6(Suppl 3):P48

Published on: 22 October 2009
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S04-06 OA. Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads

Authors: B Julg, KL Williams, S Reddy, K Bishop, PJ Goulder, T Ndung'u and BD Walker

Citation: Retrovirology 2009 6(Suppl 3):O48

Published on: 22 October 2009
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P04-21. Different human serum antibody profiles elicited by three candidate HIV vaccines using different immunization approaches

Authors: M Vaine, S Wang and S Lu

Citation: Retrovirology 2009 6(Suppl 3):P49

Published on: 22 October 2009
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0A07-01. HIV-specific CD8⁺ T-cells of vaccinees exhibit proliferative and cytotoxic capacities comparable to those of progressors

Authors: JE Rood, SA Migueles, AM Berkley, AA Compton, RP Joshi, A Duerr, J McElrath and M Connors

Citation: Retrovirology 2009 6(Suppl 3):O49

Published on: 22 October 2009
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OA07-02. Adenovirus vectors induce expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 infection

Authors: A Benlahrech, J Harris, A Meiser, T Papagatsias, J Hornig, P Hayes, A Lieber, T Athanasopoulos, V Bachy, R Daniels, K Fisher, F Gotch, L Klavinskis, L Seymour, K Logan, R Barbagallo…

Citation: Retrovirology 2009 6(Suppl 3):O50

Published on: 22 October 2009
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P04-22. Multispecific monoclonal antibodies bind to primary human macrophages and induce the production of protective chemokines, MIP-1α and MIP-1β

Authors: KL Weaver, KK Peachman, K Boonnak, L Wieczorek, GR Matyas, LM Asher, VR Polonis, M Marovich, CR Alving and M Rao

Citation: Retrovirology 2009 6(Suppl 3):P50

Published on: 22 October 2009
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