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Fig. 6 | Retrovirology

Fig. 6

From: Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle

Fig. 6

Functional disorder analysis of human LEDGF/p75 protein (UniProt ID: O75475). A Per-residue disorder profile generated by RIDAO [138]. B Functional disorder profile generated by the D2P2 platform [139]. Here, phosphorylation, ubiquitylation, sumoylation, and acetylation sites are shown by red, violet, green and yellow circles with characters P, U, S, and A, respectively. An interactive profile generated for this protein by D2P2 is available at https://d2p2.pro/view/sequence/up/O75475. C Evaluation of LLPS predisposition and existence of regions with context-dependent disorder [145]. D Model of the LEDGF/p75 structure generated by AlphaFold [147]

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