Fig. 1
From: Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
Evolving and potential roles for biomolecular condensates at various steps of the retroviral replication cycle. 1, engagement with host cell receptors and viral entry; 2, membrane fusion and intracellular trafficking of the viral capsid; 3, nuclear entry; 4, uncoating and completion of reverse transcription; 5, integration into host DNA; 6, transcription, intranuclear trafficking of the viral ribonucleoprotein; 7, nucleocytoplasmic mRNA export through the nuclear pore with completely spliced mRNAs exported first then the singly-spliced and unspliced mRNAs; 8, mRNA engagement with the host translation machinery to generate early (Tat, Rev and Nef) and late (pr55Gag, pr160Gag/Pol, Vpr, Vpu and Vif) viral gene products, as indicated, and genomic RNA selection; 9, genomic RNA and viral protein trafficking to virus assembly sites; 10, virus budding; and 11, virus maturation mediated by the viral protease substrates, pr55Gag and pr160Gag/Pol. Please see text for details on condensation at virus replication steps