HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Retrovirology

Table 6 The association between dE90 values and rate of CD4 + T cell decline

Variable	Multivariable, dE0 (n = 102)			Variable	Multivariable (n = 102)
Variable	Coeff.	SE	p value	Variable	Coeff.	SE	p value
dE90^a	− 0.05	0.07	0.51	dE90	− 0.004	0.06	0.94
				Square-root baseline CD4^b	− 0.99	0.24	< 0.0001
				Follow-up time^c	0.01	0.002	< 0.0001
				Log baseline viral load^d	− 1.24	0.9	0.17
				Cohort^e: Tshedimoso	0.15	2.57	0.95
				TRAPS	− 2.89	2.38	0.23

CD4 + T cell decline values were limited to the range of − 50 to 50 cells/mm³ per month to exclude outliers
Coeff., coefficient; SE, standard error
^adE90 values were derived from the Nef fitness landscape Potts model (each amino acid present at each residue was modelled explicitly) for each Nef clone and serve as a proxy for in vivo Nef fitness [17]
^bCD4 + counts are expressed per one square root unit increase
^cFollow-up time is expressed per day increment
^dViral load estimates are expressed per log10 increment
^eThe HPP acute infection cohort is the reference group for cohorts

ISSN: 1742-4690