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Table 1 The association between SERINC5 down-regulation and viral load set point

From: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Variable

Univariable (n = 101)

Variable

Multivariable (n = 101)

Coeff.

SE

p value

Coeff.

SE

p value

SERINC5a

0.22

0.4

0.59

SERINC5

0.46

0.42

0.28

    

Cohortb: Tshedimoso

 − 0.23

0.24

0.34

    

TRAPS

 − 0.5

0.21

0.02

  1. Coeff., coefficient; SE, standard error
  2. aSERINC5 down-regulation function is expressed relative to SF2 Nef (where SF2 function is 1 in the multivariable disease progression models as previously [15, 16])
  3. bThe HPP acute infection cohort is the reference group for cohorts