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Fig. 3 | Retrovirology

Fig. 3

From: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Fig. 3

The relationship between SERINC5 down-regulation activity and viral load set point by cohort. The SERINC5 down-regulation activity was measured for Nef clones derived from three different cohorts, namely the HPP acute infection cohort (A), the Tshedimoso cohort (B) and the TRAPS cohort (C). SERINC5 down-regulation correlated significantly with viral load set point in the Tshedimoso cohort only (Spearman’s correlation). SERINC5 down-regulation activity was expressed relative to that of SF2 Nef (100% activity)

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Retrovirology

ISSN: 1742-4690

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