Table 1 Co-receptor tropism predictions for subtypes D and A1 adopting the 5% false discovery rate from geno2pheno. Distinction is made between V3 sequences from genomes containing only one subtype and URFs
Subtype | Historic 1986 | Intermediate 1998/9 | Modern 2007-2016 | ||||||
|---|---|---|---|---|---|---|---|---|---|
X4 | R5 | Proportion X4 | X4 | R5 | Proportion X4 | X4 | R5 | Proportion X4 | |
D (genome) | 46 | 26 | 53/80 (66%) | 9 | 17 | 11/33 (33%) | 44 | 38 | 70/143 (49%) |
D env (URF) | 7 | 1 | 2 | 5 | 26 | 35 | |||
A1 (genome) | 0 | 16 | 0/24 (0%) | 0 | 5 | 0/13 (0%) | 5 | 136 | 13/256 (5%) |
A1 env (URF) | 0 | 8 | 0 | 8 | 8 | 107 | |||
Other | 0 | 1 | 0% | 0 | 0 | 0% | 5 | 55 | 8% |
Total | 53 | 52 | 50% | 11 | 35 | 24% | 88 | 371 | 19% |