Fig. 4

DEG in 12 pathways unique or shared by study groups. Orange-coding classifies DEG unique to or shared by study groups with down-regulated DEG texted green, up-regulated DEG texted red and DEG expressed in opposite directions in two study groups texted blue. #: Additional genes not shown CREBBP, FOXO1, IL1A, MAP3K3, NFAT5, PDPK1 and TLR6 in 2 pathways, and all others in a single pathway, including ACVR1B, ARID2, BCL6, BID, CFLAR, CSNK2A1, EP300, FOXP1, GAB2, IGF2R, IL4R, IL6R, LIMS1, LTB, MAP3K2, MDM2, MGAT5, MMP9, NAIP, PGF, POU2F1, PPP3CA, PTPRC, RAC1, RPS6KA2, SGK1, THEM4, TNFRSF21, TNFRSF25 and TNFSF14. $: Additional genes not shown NFATC2, STAT2, TGFBR3, TLR3 and YWHAQ in 2 pathways, and all others in a single pathway, including ACTA2, ANAPC4, ANAPC10, ATF5, BATF, BIRC2, BMPR1A, CAMK2D, CD28, CD81, CDKN2A, CYCS, E2F7, E2F8, EIF2S1, EIF4E, FANCA, FANCF, FANCM, FGFR2, FYN, HLA-DQA1, HLTF, IFITM1, IL10RA, IL12RB1, ILK, INPP5F, IRF3, IRF7, KIF11, LCK, MRE11, MX1, PARP11, PARP15, PARP2, PARP3, PDCD1, PLEKHA3, PLK4, PPP3CB, PRKAB2, PTTG1, RBBP8, RFC5, RPS6KC1, SH2D2A, SMAD3, SMARCE1, SOS1, STAT4, TAB3, TAP1 and TBX21. ‡: Additional genes not shown ATF3, ATR, AZI2, BARD1, BRIP1, C1QB, CASP3, CASP7, CCNB1, CCNB2, CDC7, CDC20, CDK1, CTLA4, DDX58, EOMES, FANCL, FBXO5, FZD1, HLA-DPA1, IFI35, IFI6, IFIH1, IFIT1, IFIT3, IRF1, ISG15, ITGA4, ITGB1, MEF2A, NBN, OAS2, OAS3, PARP12, PARP14, PDIA3, PIK3AP1, PRC1, PRDM1, PRKCH, RAD50, RFC3, ROCK1, SLK and UBE2N in a single pathway. *: Same gene which was up (↑)- and down (↓)-regulated in different groups. a: ↓ in II, ↑in V. b: ↑in II, ↓in V. c: ↓ in IV, ↑ in V