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Fig. 1 | Retrovirology

Fig. 1

From: Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana

Fig. 1

Differentially expressed genes (DEG) stratified by HIV infection and substance use. DEG analysis was performed by a pairwise comparison of the transcriptome profile between each study group (Groups I to V) to a reference group of youth without HIV-1 (YWOH) who did not use substances (n = 25). Group I (n = 9) included YWOH who used a combination of marijuana, tobacco, and alcohol; Groups II to V included youth with HIV-1 (YWH) on antiretroviral therapy (ART): II (n = 8), detectable plasma virus (+) [VL > 50 copies/ml], no substance; III to V, undetectable plasma virus (−) [VL ≤ 50 copies/ml], with no substance use [III, n = 19], marijuana use only [IV, n = 8], or marijuana combined with tobacco use [V, n = 19]. Genes showing an absolute fold change |FC| ≥ 1.3 and a permutation false discovery rate (FDR) < 0.05 were considered significantly altered in expression. Red: up-regulated DEG; Green: down-regulated DEG

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