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Table 6 Compounds targeting binding site 5: central pore binding site

From: Rotten to the core: antivirals targeting the HIV-1 capsid core

Name

Key interactions

Effects on stability and/or assembly

HIV-1 stage affected

IC50/EC50

CC50

IP6 [80]

R18, K25

Stabilize

Early/late

N/A—Not an antiviral

N/A

HCB [196]

R18

N/A

N/A

N/A

N/A

ACAi-028 [198]

Q13, T19, S16b

Destabilize

Early

0.55 µM

N/A

  1. Compound stabilizing effects on HIV-1 CA were determined by thermal shift assays and compounds effects on capsid assembly were determined by in vitro capsid assembly assays
  2. N/A not available
  3. bRefers to key interactions found through non-structural studies such as molecular docking
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Retrovirology

ISSN: 1742-4690

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