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Table 3 Compounds targeting binding site 2: CAP-1 binding site

From: Rotten to the core: antivirals targeting the HIV-1 capsid core

Name

Key interactions

Effects on stability and/or assembly

HIV-1 stage affected

IC50/EC50

CC50

CAP-1 [178]

N29, F32, S33, V36, M39, N53, V59, G60, H62, R143, M144, Y145

Decrease multimerization

Late

N/A

N/A

BD3 [177]

Helix α1

N/A

Late/early

0.4 µM

N/A

BM4 [177]

F32, H62 R162, D163, D166

N/A

Late/early

46 µM

N/A

  1. N/A not available
  2. Compound stabilizing effects on HIV-1 CA were determined by thermal shift assays and compounds effects on capsid assembly were determined by in vitro capsid assembly assays
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Retrovirology

ISSN: 1742-4690

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