Fig. 8
From: Rotten to the core: antivirals targeting the HIV-1 capsid core
HIV-1 antivirals targeting the apical binding site. A Chemical structure of benzimidazole compound 4 (from [195]). B Crystal structure of CANTD in complex with 4 (PDB ID: 4E91; compound 4 in orange sticks) in surface view. CANTD is shown in light gray, with site 4 colored in green. C Close-up view of compound 4 at site 4, colors as in (B). Residues having strong hydrophobic interactions with compound 4 are shown as light green sticks. Hydrogen bonds with the side chain of R132 are shown as black dotted lines