Fig. 7
From: Rotten to the core: antivirals targeting the HIV-1 capsid core
HIV-1 antivirals targeting the twofold binding site. A Two CA monomers from a CA hexamer (PDB ID: 4XFX) with CANTDs shown in light gray and light cyan, with the respective CACTDs in dark gray and dark cyan, and binding site 3 in yellow. B Crystal structure of CACTD in complex with CAI (PDB ID: 2BUO; CAI in cyan cartoon and sticks). Surface (left) and cartoon (right) views of CA site 3 interacting with CAI. C NMR structure of CACTD in complex with NYAD-13 (PDB ID: 2L6E; NYAD-13 in pink cartoon and sticks). Left: Surface (left) and cartoon (right) views of CA site 3 interacting with NYAD-13, which is stabilized through hydrocarbon stapling with (S)-2-(2ʹ-pentenyl) alanine (magenta cartoon and sticks)