Fig. 6From: Rotten to the core: antivirals targeting the HIV-1 capsid coreHIV-1 antivirals targeting the CAP-1 binding site. A Two CA monomers from a CA hexamer (PDB ID: 4XFX) with CANTDs shown in light gray and light cyan, respective CACTDs in dark gray and dark cyan, and binding site 2 in orange. One subunit is outlined in red. B NMR structures of CANTD in complex with CAP-1 (PDB ID: 2JPR; CAP-1 in green sticks). Left: surface and cartoon views of CA site 2 interacting with pose 1 of CAP-1. Right: surface and cartoon views of CA site 2 interacting with pose 2 of CAP-1. C Crystal structure of CANTD in complex with BD-3 (PDB ID: 4E91; BD-3 in pink sticks). Left: surface and cartoon views of CA site 2 interacting with pose 1 of BD-3. Right: surface and cartoon views of CA site 2 interacting with pose 1 of BD-3Back to article page