Skip to main content
Fig. 5 | Retrovirology

Fig. 5

From: Rotten to the core: antivirals targeting the HIV-1 capsid core

Fig. 5

Different inter-subunit interactions of various CA-targeting compounds at CA binding site 1. A Chemical structures of BI-2 and GS-6207 (PF74 is shown in Fig. 3A). B BI-2 only interacts with the N-terminal domain of HIV-1 CA. The crystal structure of HIV-1 CA hexamer in complex with BI-2 (PDB ID: 4U0F; purple sticks) was superposed to a crystal structure of HIV-1 CA hexamer in complex with PF74 (PDB ID: 4XFZ; yellow sticks). The CANTD of one CA monomer is shown in light gray cartoon with binding site 1 shown in red, the CACTD of a neighboring monomer (CACTDʹ) is shown in dark green. Residues interacting with PF74 and/or BI-2 are shown as sticks. C GS-6207 forms extended interactions with the CANTD and CACTD of a neighboring CA monomer (CANTDʹ show in light cyan cartoon and CACTDʹ shown in dark green). The crystal structure of HIV-1 CA hexamer in complex with GS-6207 (PDB ID: 6V2F; green sticks) was superposed to a crystal structure of HIV-1 CA hexamer in complex with PF74 (PDB ID: 4XFZ; yellow sticks). The CANTD of one CA monomer is shown in light gray cartoon with binding site 1 shown in red. The novel interaction with CANTDʹ is shown as a black dotted line. The R1 and R2 groups of PF74 (see Fig. 3A) superpose well to GS-6207, while the R3 group adopts a different conformation

Back to article page