Fig. 4
From: Rotten to the core: antivirals targeting the HIV-1 capsid core
Host factor FG motifs share a common binding conformation with the PF74 benzyl group. Crystal structures of HIV-1 CA hexamers in complex with CPSF6 (PDB ID: 6AY9; blue cartoon and sticks), NUP153 (PDB ID: 6AYA; orange cartoon and sticks), and Sec24C (PDB ID: 6PU1; magenta cartoon and sticks) peptides were aligned to a crystal structure of HIV-1 CA hexamer in complex with PF74 (PDB ID: 4XFZ; yellow sticks). The HIV-1 CA protein is omitted for clarity. The benzyl group of PF74 binds in a similar manner to the benzyl group of the phenylalanine in the FG motif of each host factor peptide