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Fig. 2 | Retrovirology

Fig. 2

From: Rotten to the core: antivirals targeting the HIV-1 capsid core

Fig. 2

Binding sites of CA-targeting antivirals in mature HIV-1 CA monomers and hexamers. A The five CA-targeting antiviral binding sites are shown mapped onto the HIV-1 CA monomer (PDB ID: 4XFX). CANTDs are shown in light gray, CACTDs are shown in dark gray. Binding site 1 is shown in red, binding site 2 in orange, binding site 3 in yellow, binding site 4 in green, and binding site 5 in blue. The view is rotated by 180°. B The same domains and five CA-targeting antiviral binding sites are shown mapped onto the HIV-1 CA hexamer. Colors are as described in A. The views are rotated by 90°. C Schematic outlining the domains, binding sites, and secondary structure of HIV-1 CA. Compound binding sites are colored as described in A, and the Cyclophilin A binding loop (CypA-BL) is shown as pink circles. The CANTD and CACTD are shown as light and dark gray bars, respectively. The β-hairpin (βPin) and α-helices (α) shown as gray arrows and twists, respectively. Schematic generated by Protean 3D™ (V17.2.1) from DNASTAR, Inc

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