Fig. 6
From: HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
In virio SHAPE reactivity-constrained lowest energy secondary structure of the HIV-1 5′-UTR, after treatment of cells with 10 µM BI-D. The secondary structure model was generated by applying averaged normalized SHAPE reactivity from two independent trials as pseudo free-energy constraints. Nucleotides are colored according to SHAPE reactivity as indicated in the key. Nucleotides that could not be analyzed are shown in grey. The tRNALys,3 annealing site is indicated by a black line