Editing out HIV: application of gene editing technology to achieve functional cure

Retrovirology

Table 2 Overview of past and current investigations by ZFN or TALEN in HIV therapy

Years	Target	Cell types/organisms	References
2013	Endogenous CCR5 gene	HeLa cells	Ru et al. [100]
2014	CCR5 locus	Human CD4+ T cells	Yi et al. [101]
2014	LEDGF/p75 gene, PSIP1	HT1080, 293T, and Jurkat E6 cells	Fadel et al. [102]
2014	CCR5	The CCR5-1-GHOST cell line	Mock et al. [103]
2014	HIV-1 sub-type B DNA sequences	HeLa-tat-III/LTR/d1EGFP cells	Strong et al. [104]
2015	CCR5	MSC	Manotham et al. [105]
2015	CCR5	The T-cell line PM1	Mock et al. [54]
2016	CCR5	Human hematopoietic stem/progenitor cells	DiGiusto et al. [106]
2018	The third exon of CCR5	Nucleated CD34+ cells	Chattong et al. [107]
2018	Human CCR5 gene	HeLa cells or HEK293T cells	Liu et al. [108]
2018	Long terminal repeats (LTRs)	HEK293T cells	Ji et al. [109]
2018	CCR5	HEK293T cells	Nerys-Junior et al. [110]

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