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Fig. 1 | Retrovirology

Fig. 1

From: Editing out HIV: application of gene editing technology to achieve functional cure

Fig. 1

Schematic of different gene therapy strategies against HIV. A RNA interference (RNAi) processes the double stranded RNA (dsRNA) region of pathogenic RNA into small or short interfering RNAs (siRNAs), siRNAs bind to cell proteins to form RNA induced silencing complex (RISC), which can cleave foreign RNA sequences from siRNA. B Each ZFN consists of a cleavage domain of FokI, which is fused with a zinc finger protein (ZFP), which has been customized with a gender specific “left” or “right” half site. The combination of two ZFNs makes the dimerization and DNA cleavage possible. C The TALEN elements are targeted to specific DNA sites by DNA recognition module, and then cleaved under the action of FokI nuclease. D CRISPR/Cas system consists of CRISPR sequence elements and Cas gene family. The proteins encoded by these genes have the functional domain of nuclease activity, which can specifically cut the DNA sequence. E Application of different gene editing techniques in HIV eradication

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