Skip to main content
Fig. 1 | Retrovirology

Fig. 1

From: An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation

Fig. 1

Identification of the 17-nt SPRE-core motif in syncytin-1 and syncytin-2. a Locations of SPRE sequences, which increase protein expression of HIV-1 Gag in human syncytin-1 and syncytin-2 (68-nt and 400-nt, respectively). b The alignment of the two sequences. The 17-nt common sequence is represented in red. c Schematic representation of Syncytin-1 and Syncytin-2 expression plasmids and sequences of SPRE mutants. d Fusion-dependent luciferase assay in 293T cells transfected with Syncytin-1 and Syncytin-2 expression plasmids. WT; wild-type sequence, Mut; SPRE mutant. Each value was normalized by the luminous intensity of WT. Individual data are indicated as points, and medians are indicated as bars

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us