Skip to main content

Table 4 Kinetic properties of PT binding to WT and mutant gp120 variants (HxBc2 strain)

From: Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

 

SPR

KD (nM)

k1 (M−1 s−1)

× 10–5

k-1 (s−1)

× 103

k2 (s−1)

× 103

k-2 (s−1)

× 103

AAR029b

 WT

7.8

11

8.3

–

–

 V255I

240

5.4

130

–

–

 V255I/S143N

300

3.6

110

–

–

KR13

 WT

1.1

2.9

9.6

7.0

0.25

 V255I

4.8

2.3

14

8.4

0.72

 V255I/S143N

6.5

2.8

18

9.0

1.0

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us