Table 2 Inhibitory properties of AAR029b and KR13 against HIV-1 pseudotyped with wild type and resistance Env variants
AAR029b IC50 (nM) (fold-change relative to WT) | KR13 IC50 (nM) (fold-change relative to WT) | |||
|---|---|---|---|---|
NL4-3 | HxBc2 | NL4-3 | HxBc2 | |
Wild type | 250 ± 90 (1) | 230 ± 130 (1) | 2.0 ± 0.56 (1) | 1.2 ± 0.17 (1) |
S143N | 380 ± 20 (1.5) | 540 ± 50 (2.3) | 3.5 ± 1.5 (1.8) | 1.4 ± 0.24 (1.2) |
V255I | 7.6 × 104 ± 1.6 × 104 (300) | 1.4 × 104 ± 810 (50) | 120 ± 18 (62) | 91 ± 23 (77) |
V255T | 9.1 × 104 ± 3.9 × 104 (370) | 1.5 × 104 ± 1.5 × 104 (62) | 360 ± 35 (180) | 330 ± 70 (280) |
V255I/S143N | 2.0 × 105 ± 2.6 × 104 (790) | 3.4 × 104 ± 2.9 × 104 (150) | 3700 ± 560 (1900) | 4600 ± 510 (3900) |
V255T/S143N | 2.4 × 105 ± 2.7 × 104 (980) | 3.7 × 104 ± 1.8 × 104 (160) | 6200 ± 320 (3100) | 7100 ± 1100 (6000) |