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Fig. 10 | Retrovirology

Fig. 10

From: Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Fig. 10

Proposed mechanism of PT escape. A Chemical reaction scheme depicting conformational fluctuations of unliganded (black) and PT-bound (red) Env in its prefusogenic state. B Energy levels of different conformations of unliganded and PT-bound Env. The effect of escape mutations on this energetic landscape is indicated by the purple arrow, where the asterisk represents the energy level of the mutated Env. Detailed descriptions of this model, including definitions of the different conformations, can be found in the text and Additional file 1: Figure S4

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Retrovirology

ISSN: 1742-4690

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