Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy

Table 2 Estimates of declining rate of CD4 T cell counts from the time of diagnosis to cART initiation

HIV-1 subtype	N	Decline rate (cell/µl)^1/2 /year)			Decline rate (cell/µl)^1/2/year)
HIV-1 subtype	N	Mean (95%CI)	P value	P value	Adjusted mean (95%CI)*	P value
CD4 200–350
CRF55_01B	62	13.6 (8.3, 18.9)	Ref		Ref	Ref
CRF01_AE	157	23.3 (15.9, 30.7)	< 0.05	Ref	10.3 (0.7, 19.9)	< 0.05
CRF07_BC	194	11.0 (8.4, 13.5)	0.391	< 0.01	− 2.7 (− 12.0, 6.6)	0.570
CD4 ≥ 350
CRF55_01B	52	7.9 (3.0, 12.8)	Ref		Ref	Ref
CRF01_AE	114	6.9 (5.0, 8.8)	0.702	Ref	1.4 (− 3.5, 6.2)	0.587
CRF07_BC	174	9.6 (5.6, 13.6)	0.597	0.226	0.7 (− 4.1, 5.5)	0.776
All ≥ 200
CRF55_01B	114	11.0 (7.3, 14.7)	Ref		Ref	Ref
CRF01_AE	271	16.4 (11.9, 20.9)	0.069	Ref	6.0 (− 0.3, 12.3)	0.064
CRF07_BC	368	10.3 (8.0, 12.7)	0.77	< 0.05	− 0.6 (− 6.7, 5.4)	0.837

* The Adjusted mean was estimated with adjustment of age at HIV diagnosis, ethnicity, marital status, and year of HIV diagnosis

ISSN: 1742-4690