Fig. 2

LASER ART and CRISPR-Cas9 therapies for HIV-1 elimination. Humanized mice developed (a) and HIV-1 infected humanized (b) mice were administered with sequential treatment of a combination of long-acting ART followed by CRISPR-Cas9 targeting specific sequences of the HIV-1 genome (c). Using sequential treatments, complete HIV-1 elimination from a subset of animals. This combinatorial approach is being developed for improved delivery of CRISPR-Cas9 to target the latent reservoirs in humanized mouse models (left panel), to improve the rates of viral elimination (right panel) (Color explanation: blue color cells are represented as human cells, red color cells are represented HIV-1 infected cells and green color represents the cells with complete elimitation of HIV-1)