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Fig. 2 | Retrovirology

Fig. 2

From: Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

Fig. 2

Comparison of trend in bnAb sensitivity across time against VRC01, CAP256-VRC26.25, PGDM1400 and PGT121. Top panel. Scatter plots of IC50 values for clones reported in the CATNAP database were grouped as 1990–2000, 2001–2010 and 2011–2016 for viruses from India along with those reported in the present study (indicated by larger dots). Bottom panel. Scatter plots of IC50 values for Env-pseudotyped viruses reported in the CATNAP database were grouped as 1990–2000, 2001–2005 and 2006–2010 for envs from Pan-Africa. Data points were color-coded based on the disease stage at sampling of the respective viruses. IC50 value of 5 µg/mL was considered as a threshold of neutralization sensitivity. Statistical assessment of increase in the IC50 values was performed with Jonckheere-Terpstra test (JTT)

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Retrovirology

ISSN: 1742-4690

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