Fig. 7
From: A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
Sequence analysis and construction of mutants in K3016, IndieC1 and ZM247 viral backbone. a Amino acid sequence alignment of the SP1 region of the HIV-1 subtype C clones, K3016, IndieC1 and ZM247. b Sequence logos for HIV-1 subtype C (1994 sequences) SP1 residues derived from the curated Los Alamos HIV-1 sequence database. Positions of amino acid residues are numbered (X-axis). Conservation of a residue is shown as a function of probability of its occurrence at a particular position (Y-axis). Blue, green and black indicates hydrophilic, neutral and hydrophobic amino acids respectively. Red arrows indicate positions of amino acids selected for our study. c Construction of HIV-1 subtype C SP1 mutants (underlined). Dashes represent residues that are identical to the parental sequence