Fig. 7
From: Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread
HTLV-1 2 k EVs promote enhanced viral spread. a Presence of proviral DNA (using qPCR for env region) from blood and tissues from multiple organs (Spleen, Liver, L.N., and Brain) of NOG mice (n = 12) treated with control (NOG 1–3), 2 k (NOG 4–6), 10 k (NOG 7–9), and 100 k (NOG 10–12) EVs followed by HUT102 donor cells (IRed) treatment 5 days later. b Presence of RNA (using RT-qPCR env RNA) from blood and tissues of NOG mice (n = 12) treated with control (NOG 1–3), 2 k (NOG 4–6), 10 k (NOG 7–9), and 100 k (NOG 10–12) EVs followed with HUT102 donor cells (IRed) treatment 5 days later. A two-tailed student t-test was used to evaluate statistical significance with “*” for p-values ≤ 0.05, “**” for p-values ≤ 0.01, and “***” for p-values ≤ 0.001, indicating the level of significance compared to control