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Table 4 Association between KoRV RNA and DNA subtype detection and selected koala characteristics by subject for blood samples

From: Koala retrovirus diversity, transmissibility, and disease associations

Characteristic

KoRV-B

KoRV-E

KoRV-F

 

Positive (N = 16)

Negative (N = 84)

p value

Positive (N = 8)

Negative (N = 92)

p value

Positive (N = 12)

Negative (N = 88)

p value

RNA

         

 Age (years)

5.5

5.8

0.8

4.4

5.9

0.4

4.8

5.9

0.4

 Sex

  

0.4

  

0.2

  

0.3

  Female

8 (50.0%)

39 (46.4%)

 

6 (75.0%)

41 (44.6%)

 

8 (66.7%)

39 (44.3%)

 

  Male

8 (50.5%)

37 (44.0%)

 

1 (12.5%)

44 (47.8%)

 

4 (33.3%)

41 (46.6%)

 

  Joey

0 (0.0%)

8 (9.5%)

 

1 (12.5%)

7 (7.6%)

 

0 (0.0%)

8 (9.1%)

 

 Health status classification and cause of deatha

  

0.002

  

0.07

  

0.003

  Alive

6 (37.5%)

60 (71.4%)

 

4 (50.0%)

62 (67.4%)

 

5 (41.7%)

61 (69.3%)

 

  Leukemia-lymphoma and other cancer

6 (37.5%)

6 (7.1%)

 

3 (37.5%)

9 (9.8%)

 

5 (41.7%)

7 (8.0%)

 

  Other

4 (25.0%)

18 (21.4%)

 

1 (12.5%)

21 (22.8%)

 

2 (16.7%)

20 (22.7%)

 

 Location

  

 < 0.0001

  

0.0003

  

 < 0.0001

  Australian zoos

13 (81.3%)

14 (16.7%)

 

7 (87.5%)

20 (21.7%)

 

10 (83.3%)

17 (19.3%)

 

  US zoos

3 (18.8%)

49 (58.3%)

 

1 (12.5%)

51 (55.4%)

 

2 (16.7%)

50 (56.8%)

 

  Wild

0 (0.0%)

21 (25.0%)

 

0 (0.0%)

21 (22.8%)

 

0 (0.0%)

21 (23.9%)

 

Characteristic

Positive (N = 18)

Negative (N = 82)

p value

Positive (N = 11)

Negative (N = 89)

p value

Positive (N = 10)

Negative (N = 90)

p value

DNA

         

 Age (years)

4.9

6

0.3

5.7

5.8

1

4.5

5.9

0.4

 Sex

  

0.9

  

0.4

  

0.08

  Female

9 (50.0%)

38 (46.3%)

 

7 (63.6%)

40 (44.9%)

 

8 (80.0%)

39 (43.3%)

 

  Male

8 (44.4%)

37 (45.1%)

 

4 (36.4%)

41 (46.1%)

 

2 (20.0%)

43 (47.8%)

 

  Joey

1 (5.6%)

7 (8.5%)

 

0 (0.0%)

8 (9.0%)

 

0 (0.0%)

8 (8.9%)

 

 Health status classification and cause of deatha

  

0.009

  

0.3

  

0.0005

  Alive

9 (50.0%)

57 (69.5%)

 

6 (54.6%)

60 (67.4%)

 

4 (40.0%)

62 (68.9%)

 

  Leukemia-lymphoma and other cancer

6 (33.3%)

6 (7.3%)

 

3 (27.3%)

9 (10.1%)

 

5 (50.0%)

7 (7.8%)

 

  Other

3 (16.7%)

19 (23.2%)

 

2 (18.2%)

20 (22.5%)

 

1 (10.0%)

21 (23.3%)

 

 Location

  

 < 0.0001

  

 < 0.0001

  

0.0003

  Australian zoos

15 (83.3%)

12 (14.6%)

 

11 (100.0%)

16 (18.0%)

 

8 (80.0%)

19 (21.1%)

 

  US zoos

3 (16.7%)

49 (59.8%)

 

0 (0.0%)

52 (58.4%)

 

2 (20.0%)

50 (55.6%)

 

  St. Bees Island (wild)

0 (0.0%)

21 (25.6%)

 

0 (0.0%)

21 (23.6%)

 

0 (0.0%)

21 (23.3%)

 
  1. KoRV was considered detected if any sample at any time point from a koala tested positive for that specific subtype
  2. aCauses of death at study conclusion are listed for other than alive. Other cancers included osteoma, metastatic sarcoma, osteosarcoma, hemangiosarcoma, and mammary carcinoma. Other causes of death included anemia, old age, euthanasia, acute respiratory illness, intestinal volvulus, torsion, intussusception, pulmonary interstitial fibrosis, unknown, and early young pouch death. The most common lesion in koalas that were classified with death at old age was degenerative joint disease