TY - JOUR AU - Millen, Sebastian AU - Meretuk, Lina AU - Göttlicher, Tim AU - Schmitt, Sarah AU - Fleckenstein, Bernhard AU - Thoma-Kress, Andrea K. PY - 2020 DA - 2020/09/10 TI - A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells JO - Retrovirology SP - 30 VL - 17 IS - 1 AB - Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region (Tax) is important for initiating malignant transformation, and deregulation of the major signaling pathway nuclear factor of kappa B (NF-κB) by Tax represents a hallmark of HTLV-1 driven cancer. SN - 1742-4690 UR - https://doi.org/10.1186/s12977-020-00538-w DO - 10.1186/s12977-020-00538-w ID - Millen2020 ER -