Table 1 Alleles previously associated with either protection or susceptibility to HTLV-1 associated diseases
|
Country/Continent (Reference) | N, Population | Protective allele | Detrimental allele |
|---|---|---|---|
| Africa [52] |
N = 45, Ac N = 49, ATLL N = 51, NII | – |
HLA-A*36 HLA-B*18 |
| Brazil [18, 19] |
N = 71, HTLV-1 + N = 188, NII | HLA-A*02 (HAM) | HLA-A*26 (ATLL) |
|
N = 53, Ac N = 55, HAM | HLA-A*02 | – | |
| Spain [14] |
N = 40, Ac N = 20, HAM | – |
HLA-B*5401 absent HLA-B*07 |
| Iran [22, 24, 49] |
N = 74, Ac N = 58, HAM | – | HLA-B*5401 |
|
Iranian N = 74, Ac N = 58, HAM Kagoshima N = 184, Ac N = 222, HAM | HLA-Cw*08 | – | |
|
N = 20, HAM N = 30, Ac |
No association: HLA-A*02 HLA-A*24 HLA-Cw*08 | – | |
| Jamaica [17, 28] |
N = 45, Ac N = 25, ATLL |
HLA-A*02 HLA-A*33 |
HLA-A*03 HLA-A*36 |
|
N = 56, ATLL N = 59, HAM | HLA-A*03 |
HLA-B*15 HLA-B*53 | |
| Japan [16, 20, 23, 53] |
N = 34, ATLL N = 55, HAM N = 241, AC | – |
HLA-A*26 (ATLL) HLA-B*61 (ATLL) HLA-B*07 (HAM) HLA-Cw*07 (HAM) |
|
N = 175, NII N = 152, Ac N = 124, ATLL N = 148, HAM | – |
HLA-A*26 HLA-B*4002 HLA-B*4006 HLA-B*4801 | |
|
N = 233, HAM N = 202, NII |
HLA-A*02 HLA-Cw*08 | HLA-B*5401 | |
|
N = 201, Ac N = 232, HAM |
HLA-A*0201 HLA-Cw*0801 | HLA-B*5401 | |
| Peru [21] |
N = 71, HAM N = 94, Ac | HLA-A*02 | – |