Fig. 4
From: Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma
Identification of IRF4 regulated genes in CD4 + T-cells in vivo. a CD45.1 HSC were transduced with IRF4 expressing retroviral vectors and engrafted into CD45.2 hosts. Peripheral blood was collected and mice were euthanized after 4 weeks. RNAseq was performed on CD45.1, GFP + , CD4 + T-cells purified by FACS from pooled thymocytes. b Genes elevated in CD4 + T-cells expressing IRF4 compared to CD4 + T-cells with empty vector. c Transcription factor networks associated with gene list identified using the ChEA3 Transcription Factor Local Network Analysis of Top Gene Hits (https://amp.pharm.mssm.edu/chea3/#top)