Table 5 Average number of hydrogen bonds between residues D30 and K45 for protease wildtype and mutant complexes
Drug | Genotype | D30–K45 | D30\(^\prime\)–K45\(^\prime\) | ||
|---|---|---|---|---|---|
L76 | V76 | L76 | V76 | ||
ATV | FB15 | \(0.068\pm 0.003\) | \(0.52\pm 0.04\) | \(0.07 \pm 0.002\) | \(0.58 \pm 0.02\) |
SQV | FB15 | \(0.12 \pm 0.01\) | \(0.59\pm 0.02\) | \(0.11 \pm 0.005\) | \(0.62 \pm 0.004\) |
ATV | GH9 | \(0.07 \pm 0.01\) | \(0.49\pm 0.12\) | \(0.06 \pm 0.002\) | \(0.66 \pm 0.12\) |
SQV | GH9 | \(0.07 \pm 0.004\) | \(0.46\pm 0.04\) | \(0.01 \pm 4\times 10^{-5}\) | \(0.19 \pm 0.04\) |
ATV | RU1 | \(0.05 \pm 0.001\) | \(0.43\pm 0.05\) | \(0.04 \pm 1\times 10^{-4}\) | \(0.61 \pm 0.09\) |
LPV | RU1 | \(0.01 \pm 3\times 10^{-5}\) | \(0.16\pm 0.03\) | \(0.16 \pm 0.006\) | \(0.56 \pm 0.12\) |
ATV | iZ2 | \(0.16 \pm 0.007\) | \(0.57\pm 0.07\) | \(0.08 \pm 0.002\) | \(0.52 \pm 0.04\) |
IDV | iZ2 | \(0.1 \pm 0.01\) | \(0.39\pm 0.03\) | \(0.06 \pm 0.002\) | \(0.51\pm 0.07\) |
LPV | iZ2 | \(0.04 \pm 5\times 10^{-4}\) | \(0.19\pm 0.02\) | \(0.24 \pm 0.01\) | \(0.63\pm 0.02\) |