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Table 1 RF values for different mutant and corresponding wildtype sequences from HIVdb [30]

From: Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

Mutation

Background polymorphisms

RF

IDV

SQV

LPV

FPV

M46I

 Wildtype [33]

V3I, S37N, A71V

0.6, 1.0, 1.2

–

–

0.3, 0.6, 0.7

 Mutant [83]

4.4

–

–

2.2

I50L

 Wildtype [33]

V3I, S37N, A71V

0.6, 1.0, 1.2

–

–

0.3, 0.6, 0.7

 Mutant [33]

0.1, 0.3, 0.3

–

–

0.2, 0.2, 0.3

I84V

 Wildtype [84]

V3I, L10F, S37N

1.5

1.3

1.6

1.8

 Mutant [84]

2.1, 3.2

2.7, 3.7

6.2, 7.7

4.6, 8.4

N88S

 Wildtype [6]

V3I, S37N, L63P, R57G/L77Ia

1.1

–

–

1.0

 Mutant [6]

2.6

–

–

0.1

  1. First column indicates the mutation analysed, while the second column indicates background polymorphisms that are present in both wildtype and mutant sequences compared to the reference HIV sequence HXB2. Multiple RF measurements for the same protein are separated by comma. M46I wildtype and mutant measurements reported from different studies, but performed using the same susceptibility test method (Phenosense, Monogram, San Francisco, USA)
  2. a Indicates that the R57G background mutation was found in sequences where RF for IDV was measured and L77I in sequences where RF for FPV was measured