Fig. 1

p13 domain structure. Schematic representation of the domain structure of p13. AA indicates the amphipathic α-helix overlapping with the mitochondrial targeting signal (MTS, amino acids 21–35) and +++ indicates the four arginines present in the MTS. The transmembrane region (TM) includes amino acids 30–40. A region with a high flexibility score (H) spans amino acids 42–48. A predicted β-sheet structure spans amino acids 65–75. The proline-rich C-terminus contains two overlapping P-x-x-P motifs implicated in interactions with SH3 domain-containing proteins. A putative cryptic nuclear localization sequence (NLS) is mapped to a region spanning residues 43–80. This figure was adapted from Figure 1 in [87]