Table 2 The biological pathway which the hub genes in each group were enriched

normal vs. ACs

Module 1

Metabolism of RNA, mRNA splicing, RNA transport, HIV Infection, Rev-mediated nuclear export of HIV RNA, Infectious disease, viral messenger RNA synthesis, and mRNA processing

Module 2

rRNA processing, Metabolism of RNA, Viral mRNA Translation, Infectious disease, and Ribosome biogenesis in eukaryotes

Module 3

MicroRNAs in cancer, RNA polymerase II transcription, pathways in cancer, Cell cycle, signaling by NOTCH, regulation of RUNX1 expression and activity, p53 signaling pathway, human T-cell leukemia virus 1 infection, Transcriptional regulation by RUNX1, and transcriptional misregulation in cancer

Module 4

Ubiquitin mediated proteolysis, Class I MHC mediated antigen processing & presentation, antigen processing: ubiquitination & proteasome degradation, adaptive immune system, and immune system

normal vs. HAM/TSP

Interferon signaling, cytokine signaling in immune system, interferon alpha/beta signaling, immune system, interferon gamma signaling, JAK-STAT signaling pathway, interleukin-6 family signaling, and signaling by interleukins

ACs vs. HAM/TSP

Transcriptional regulation by RUNX2 and regulation of RUNX2 expression and activity