Fig. 3

Venn diagram showing overlap between gene regions containing a RcRE and genes altered after HIV infection or differentially expressed in hECC in response to Rec. The dataset named RcRE contained sequences in gene regions that were highly similar to the HERV-K prRcRE. The dataset named HIV, contained a list of genes that were shown to be changed after HIV-1 infection [32]. The dataset named Rec contained genes that were differentially expressed in human embryonic carcinoma cells (hECC) expressing HERV-K Rec [45]. Three genes, CEBPZ, SLC44A5 and SLC3A2, were common to all three datasets. A fourth annotated gene, TMEM64, was shared between the Rec and RcRE datasets, but was absent from the HIV dataset. Ten additional annotated genes from the HIV dataset contained RcREs, however, these genes were absent from the Rec dataset. The RcREs located within CNTLN and TPRG1 are in the same transcriptional orientation as the gene, while the remaining RcREs are anti-sense to the transcriptional orientation of their associated gene