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Fig. 5 | Retrovirology

Fig. 5

From: p30 protein: a critical regulator of HTLV-1 viral latency and host immunity

Fig. 5

p30 induces c-Myc acetylation that promotes the oncogenic transformation of HTLV-1 infected cells. The viral protein p30 interacts with TIP60 and p300/CBP, inducing acetylation of the oncoprotein c-Myc and leading to the transcription of c-Myc target genes. Moreover, p30 inhibits c-Myc-dependent apoptosis induced by genotoxic stress, which might promote the acquisition of genetic mutations that support oncogenic transformation. In addition, p30 activates the tumor suppressor p53 and induces Tp53-induced glycolysis and apoptosis regulator (TIGAR). Importantly, TIGAR prevents the intracellular accumulation of c-Myc-induced ROS, inhibits oncogene-induced cellular senescence in ATL cells, and promotes cell survival

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