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Fig. 3 | Retrovirology

Fig. 3

From: p30 protein: a critical regulator of HTLV-1 viral latency and host immunity

Fig. 3

p30 blocks cell cycle progression. In the absence of the p30 viral protein, CDK2 and cyclin E interact and mediate the phosphorylation of Rb. When Rb is phosphorylated, it releases the transcription factor E2F that translocates into the nucleus, and activates the transcription of the G1/S transition genes to promote T-cell proliferation. The viral p30 disrupts the interaction between CDK2 and cyclin E and the ability of this complex to phosphorylate Rb. In this context, E2F is sequestered by Rb and is unable to activate the expression of G1/S transition genes, leading to cell cycle arrest

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