Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment

Table 4 ART status on mean (a) CCA intima-media thickness and (b) carotid distensibility

	ART-naïve	First-line ART	p	Second-line ART	p
(a) ART status and mean CCA intima-media thickness
Model 1	REF	0.014 (− 0.011 to 0.039)	0.259	0.067 (0.046 to 0.088)	< 0.001
Model 2	REF	− 0.002 (− 0.022 to 0.018)	0.829	0.009 (− 0.010 to 0.028)	0.341
Model 3	REF	− 0.002 (− 0.023 to 0.018)	0.826	0.011 (− 0.008 to 0.029)	0.272
Model 4^a	REF	− 0.012 (− 0.038 to 0.014)	0.360	− 0.016 (− 0.046 to 0.014)	0.291
(b) ART status and carotid distensibility (10⁻⁶ N⁻¹ m²) (n = 366)
Model 1	REF	− 2.679 (− 7.221 to 1.864)	0.247	− 5.629 (− 9.417 to − 1.841)	0.004
Model 2	REF	− 0.565 (− 4.816 to 3.686)	0.794	1.166 (− 2.755 to 5.087)	0.559
Model 3	REF	− 0.562 (− 4.819 to 3.694)	0.795	1.107 (− 2.855 to 5.070)	0.583
Model 4^b	REF	1.090 (− 3.698 to 5.879)	0.654	− 0.042 (− 5.646 to 5.563)	0.988

β-coefficient with 95% CI
Model 1 unadjusted
Model 2 adjusted for age
Model 3 adjusted for age and sex
Model 4 adjusted for age, sex, systolic blood pressure, body mass index, LDL cholesterol, HDL cholesterol, glucose, current smoking, CD4+ cell count, HIV viral load and duration since HIV infection
ART antiretroviral therapy, CCA common carotid artery, IMT intima media thickness
^an = 57 (14.9%) participants were excluded from this model due to missing data in one or more covariates
^bn = 56 (15.3%) participants were excluded from this model due to missing data in one or more covariates

ISSN: 1742-4690